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- Title
A Long-Range Foresight for the Medical Application of Apoptosis Specifically Induced by Dd-MRP4, Dictyostelium Mitochondrial Ribosomal Protein S4, to Cancer Therapy.
- Authors
Yasuo Maeda
- Abstract
Apoptosis (programmed cell death) is regarded as ultimate differentiation of the cell. We have recently demonstrated that a targeted delivery of Dd-MRP4 (Dictyostelium mitochondrial ribosomal protein S4) suppresses specifically the proliferation of the human cancer cells, by inducing their apoptotic cell death (Chida et al., 2014, doi:10.1186/1475-2867-14-56). This amazing fact was discovered, simply based on the finding that Dd-MRP4 expression is absolutely required for transition of Dictyostelium cells from growth to differentiation (Chida et al., 2008, doi:10.1186/1471-2156-9-25; Maeda et al., 2013, doi:10.3390/biom3040943). Dd-MRP4 protein has quite unique structural characters, in that it is highly basic (pI: about 11.5) and interestingly has several nuclear-localization signals within the molecule. In this review, we introduce briefly the efficacy of several apoptosis-inducing substances reported thus far for cancer therapy, and speculate the possible mechanisms, by which apoptosis is specifically induced by Dd-MRP4, on the basis of its structural uniqueness. We also discuss several issues to be solved for the medical application of ectopically expressed Dd-MRP4 in human cancer cells.
- Subjects
DICTYOSTELIUM; RIBOSOMAL proteins; RIBOSOME recycling factor; INITIATION factors (Biochemistry); CANCER treatment; CANCER cells; DICTYOSTELIACEAE
- Publication
Biomolecules (2218-273X), 2015, Vol 5, Issue 1, p113
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom5010113