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- Title
Highly Pathogenic Clone of Shiga Toxin-Producing Escherichia coli O157:H7, England and Wales.
- Authors
Byrne, Lisa; Dallman, Timothy J.; Adams, Natalie; Mikhail, Amy F. W.; McCarthy, Noel; Jenkins, Claire
- Abstract
We used whole-genome sequencing to investigate the evolutionary context of an emerging highly pathogenic strain of Shiga toxin-producing Escherichia coli (STEC) O157:H7 in England and Wales. A timed phylogeny of sublineage IIb revealed that the emerging clone evolved from a STEC O157:H7 stx-negative ancestor ≈10 years ago after acquisition of a bacteriophage encoding Shiga toxin (stx) 2a, which in turn had evolved from a stx2c progenitor ≈20 years ago. Infection with the stx2a clone was a significant risk factor for bloody diarrhea (OR 4.61, 95% CI 2.24-9.48; p<0.001), compared with infection with other strains within sublineage IIb. Clinical symptoms of cases infected with sublineage IIb stx2c and stx-negative clones were comparable, despite the loss of stx2c. Our analysis highlighted the highly dynamic nature of STEC O157:H7 Stx-encoding bacteriophages and revealed the evolutionary history of a highly pathogenic clone emerging within sublineage IIb, a sublineage not previously associated with severe clinical symptoms.
- Subjects
WALES; ENGLAND; ESCHERICHIA coli O157:H7; VEROCYTOTOXINS; PATHOGENIC microorganisms; ENTEROBACTERIACEAE; MICROBIAL virulence; DIAGNOSIS of escherichia coli diseases; COMPARATIVE studies; ESCHERICHIA coli; ESCHERICHIA coli diseases; BIOLOGICAL evolution; GENETIC polymorphisms; GENOMES; RESEARCH methodology; MEDICAL cooperation; RESEARCH; GENOMICS; EVALUATION research; SEVERITY of illness index
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 12, p2303
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2412.180409