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- Title
Risk Factors for Pandemic (HIN1) 2009 Virus Seroconversion among Hospital Staff, Singapore.
- Authors
Chen, Mark I. C.; Lee, Vernon J. M.; Barr, Ian; Cui Lin; Goh, Rachelle; Lee, Caroline; Singh, Baldev; Tan, Jessie; Wei-Yen Lim; Cook, Alex R.; Ang, Brenda; Chow, Angela; Boon Huan Tan; Loh, Jimmy; Shaw, Robert; Kee Seng Chia; Lin, Raymond T. P.; Yee Sin Leo
- Abstract
We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June-September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June-October 2009, with seroconversion defined as a ≥4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009. Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Significant risk factors on multivariate analysis were being a nurse (adjusted odds ratio [aOR] 4.5, 95% confidence interval [CI] 1.0-19.6) and working in pandemic (H1N1) 2009 isolation wards (aOR 4.5, 95% CI 1.3-15.6). Contact with pandemic (H1N1) 2009-infected colleagues (aOR 2.5, 95% CI 0.9-6.6) and larger household size (aOR 1.2, 95% CI 1.0-1.4) were of borderline significance. Our study suggests that seroconversion was associated with occupational and nonoccupational risk factors.
- Subjects
SINGAPORE; H1N1 influenza; PANDEMICS; MEDICAL care; MEDICAL personnel; SEROLOGY
- Publication
Emerging Infectious Diseases, 2010, Vol 16, Issue 10, p1554
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1610.100516