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- Title
Crown–rump lengths in missed miscarriages and trisomy 21.
- Authors
Ginsberg, N. A.; Strom, C.; Verlinsky, Y.
- Abstract
ABSTRACT Objectives To compare crown–rump lengths with karyotypes of missed miscarried fetuses and to determine a relationship between crown–rump length and trisomy 21. Study design Chorionic villus sampling was performed on 129 consecutive missed miscarriages between 10 and 12 weeks by last menstrual period in patients ≥ 35 years of age. Crown–rump length was correlated with the karyotype. Statistical analysis was performed using Student’s t-test. Results Twenty-one of 129 missed miscarriages involved fetuses affected by trisomy 21. The crown–rump length was < 22 mm in 77% of missed miscarriages. Using a crown–rump length of ≥ 22 mm for the prediction of trisomy 21 had a sensitivity of 86%, specificity of 89%, positive predictive value of 60% and negative predictive value of 97%. At 10–12 weeks, the crown–rump lengths of missed miscarried fetuses with trisomy 21 was significantly larger (P ≤ 0.0001) than that of the population average of missed miscarried fetuses. Conclusion In women ≥ 35 years of age, with a missed miscarriage, in whom pregnancies reached ≥ 10 weeks from the last menstrual period, a fetal crown–rump length of ≥ 22 mm has a high probability that the etiology of the loss will be secondary to trisomy 21.
- Subjects
KARYOTYPES; DOWN syndrome; ABORTION
- Publication
Ultrasound in Obstetrics & Gynecology, 2001, Vol 18, Issue 5, p488
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1046/j.0960-7692.2001.00571.x