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- Title
GABA- and Glycine-Mimetic Responses of Linalool on the Substantia Gelatinosa of the Trigeminal Subnucleus Caudalis in Juvenile Mice: Pain Management through Linalool-Mediated Inhibitory Neurotransmission.
- Authors
Phuong, Thao Nguyen Thi; Jang, Seon Hui; Rijal, Santosh; Jung, Woo Kwon; Kim, Junghyun; Park, Soo Joung; Han, Seong Kyu
- Abstract
Linalool, a major odorous constituent in essential oils extracted from lavender, is known to have a wide range of physiological effects on humans including pain management. The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) is involved in transmission of orofacial nociceptive responses through thin myelinated A δ and unmyelinated C primary afferent fibers. Up to date, the orofacial antinociceptive mechanism of linalool concerning SG neurons of the Vc has not been completely clarified yet. To fill this knowledge gap, whole-cell patch-clamp technique was used in this study to examine how linalool acted on SG neurons of the Vc in mice. Under a high chloride pipette solution, non-desensitizing and repeatable linalool-induced inward currents were preserved in the presence of tetrodotoxin (a voltage-gated Na + channel blocker), CNQX (a non-NMDA glutamate receptor antagonist), and DL-AP5 (an NMDA receptor antagonist). However, linalool-induced inward currents were partially suppressed by picrotoxin (a GABA A receptor antagonist) or strychnine (a glycine receptor antagonist). These responses were almost blocked in the presence of picrotoxin and strychnine. It was also found that linalool exhibited potentiation with GABA- and glycine-induced responses. Taken together, these data show that linalool has GABA- and glycine-mimetic effects, suggesting that it can be a promising target molecule for orofacial pain management by activating inhibitory neurotransmission in the SG area of the Vc.
- Subjects
NEURAL transmission; BRAIN; GLYCINE; NEURONS; LAVENDERS; ANIMAL experimentation; FACIAL pain; GABA; RESEARCH funding; DESCRIPTIVE statistics; HISTOLOGY; PAIN management; MICE
- Publication
American Journal of Chinese Medicine, 2021, Vol 49, Issue 6, p1437
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X21500671