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- Title
Pharmacological Studies on Anti-Hyperglycemic Effect of Folium Eriobotryae.
- Authors
Li, Wei-Lin; Wu, Ju-Lan; Ren, Bing-Ru; Chen, Jian; Lu, Chang-Gen
- Abstract
Folium Eriobotryae, dried leaves of Eriobotrya japonica (Thunb.) Lindl. is a traditional Chinese medicine with rich resources in China. This research investigated the anti-hyperglycemic effect of Folium Eriobotryae on normal and alloxan-diabetic mice. The 70% ethanol extract of Folium Eriobotryae (EJA-0) in doses of 15, 30 and 60 g (crude drug)/kg exerted a significant hypoglycemic effect on alloxan-diabetic mice, among which 30 g/kg of EJA-0 was more effective than 100 mg/kg of phenformin. The total sesquiterpenes (EJA-1) 30 g (crude drug)/kg had significant effect on lowering blood glucose level in normal or/and alloxan-diabetic mice. The tests of maximum dosage and acute toxicity showed that EJA-1 was safe (MD = 360 g/kg, LD50 = 400.1 g/kg). The pharmacological tests on anti-hyperglycemic effects of EJA-0 and EJA-1 prove that Folium Eriobotryae is an outstanding material to develop medicine for treatment of diabetes mellitus.
- Subjects
LOQUAT; ERIOBOTRYA; CHINESE medicine; HYPOGLYCEMIC agents; ALLOXAN; MEDICAL research
- Publication
American Journal of Chinese Medicine, 2007, Vol 35, Issue 4, p705
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X07005193