We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Changes on chest HRCT in systemic sclerosis-related interstitial lung disease after autologous haematopoietic stem cell transplantation.
- Authors
Pugnet, Grégory; Petermann, Antoine; Collot, Samia; Otal, Philippe; Lansiaux, Pauline; Abdallah, Nassim Ait; Lorillon, Gwenaëlle; Resche-Rigon, Mathieu; Borel, Cécile; Marjanovic, Zora; Farge, Dominique; network, for the MATHEC-SFGM-TC
- Abstract
Objective To evaluate extent of interstitial lung disease (ILD) and oesophageal involvement using high-resolution computed tomography (HRCT) in early diffuse SSc patients after autologous haematopoietic stem cell transplantation (aHSCT). Methods Overall chest HRCT, lung function and skin score changes were evaluated in 33 consecutive diffuse SSc patients before and after aHSCT during yearly routine follow-up visits between January 2000 and September 2016. Two independent radiologists blindly assessed the ILD extent using semi-quantitative Goh and Wells method, the widest oesophageal diameter (WOD) and the oesophageal volume (OV) on HRCT. Patients were retrospectively classified as radiological responders or non-responders, based on achieved stability or a decrease of 5% or more of HRCT-ILD at 24 months post-aHSCT. Results Using a linear mixed model, the regressions of the extent of ILD and of ground glass opacities were significant at 12 months (ILD P = 0.001; ground glass opacities P = 0.0001) and at 24 months (ILD P = 0.007; ground glass opacities P = 0.0008) after aHSCT, with 18 patients classified as radiological responders (probability of response 0.78 [95% CI 0.58, 0.90]). Meanwhile the WOD and the OV increased significantly at 12 months (WOD P = 0.03; OV P = 0.34) and at 24 months (WOD P = 0.002; OV P = 0.007). Kaplan–Meier analyses showed a trend towards better 5-year survival rates (100% vs 60%; hazard ratio 0.23 [95% CI 0.03, 1.62], P = 0.11) among radiological responders vs non-responders at 24 month follow-up after aHSCT. Conclusion Real-world data analysis confirmed significant improvement in extent of HRCT SSc-ILD 24 months after aHSCT, although oesophageal dilatation worsened requiring specific attention.
- Subjects
LUNG physiology; PATIENT aftercare; CONFIDENCE intervals; INTERSTITIAL lung diseases; SYSTEMIC scleroderma; RETROSPECTIVE studies; REGRESSION analysis; TREATMENT effectiveness; POSTOPERATIVE period; SYMPTOMS; KAPLAN-Meier estimator; SURVIVAL analysis (Biometry); DESCRIPTIVE statistics; COMPUTED tomography; ESOPHAGUS diseases; HEMATOPOIETIC stem cell transplantation; MEDICAL appointments; ESOPHAGEAL stenosis
- Publication
Rheumatology, 2023, Vol 62, pSI32
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keac319