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- Title
Interactions of cytokine gene polymorphisms in prostate cancer risk.
- Authors
Jovanny Zabaleta; Hui-Yi Lin; Rosa A. Sierra; M.Craig Hall; Peter E. Clark; Oliver A. Sartor; Jennifer J. Hu; Augusto C. Ochoa
- Abstract
Prostate cancer (CaP) is the second leading cause of cancer death in American men. Chronic inflammation has been one of several factors associated with the development of CaP. Single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with increased inflammation, increased cytokine production and possibly increased CaP risk. However, the effects of cytokine SNPs on CaP susceptibility have not been consistent. Using the genomic DNA collected in a CaP caseâcontrol study (557 cases and 547 controls), we pilot tested the interactions of nine functionally characterized SNPs of three cytokine genes in CaP risk using the multivariate adaptive regression splines (MARS)âlogit models. African-Americans with the IL10â819TT genotype had a lower CaP risk [odds ratio (OR) = 0.27, 95% confidence interval (CI) = 0.07â1.01], but subjects with the genotype combination of IL1Bâ511CT/TT and IL10â592CC had a higher CaP risk (OR = 2.56, 95% CI = 1.09â6.02). In Caucasians, higher CaP risk was associated with the IL10â1082AG/GG genotype (OR = 3.62, 95% CI = 1.42â9.28), the genotype combination of IL10â1082AA plus IL1Bâ31TT/TC (OR = 2.92, 95% CI = 1.13â7.55) and the genotype combination of TNFâ238GG plus IL10â592AA (OR = 2.14, 95% CI = 1.05â4.38). Our results highlight the importance of cytokine SNPs and their interactions in CaP risk.
- Subjects
CYTOKINES; GENETIC polymorphisms; PROSTATE; CANCER research
- Publication
Carcinogenesis, 2008, Vol 29, Issue 3, p573
- ISSN
0143-3334
- Publication type
Article