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- Title
Circulating Apelin is increased in patients with type 1 or type 2 diabetes and is associated with better glycaemic control.
- Authors
Habchi, Marana; Duvillard, Laurence; Cottet, Vanessa; Brindisi, Marie‐Claude; Bouillet, Benjamin; Beacco, Maud; Crevisy, Elodie; Buffier, Perrine; Baillot‐Rudoni, Sabine; Verges, Bruno; Petit, Jean‐Michel
- Abstract
Context Apelin is an adipokine expressed in several tissues and it appears to be involved in energy metabolism. Objective The aim of this study was to determine serum apelin levels in a large cohort of patients with type 1 and type 2 diabetes and control subjects and to correlate the results with glycaemic control. Design and Participants One hundred and thirty patients with type 1 diabetes, 98 patients with type 2 diabetes and 162 controls were enrolled in the study. Apelin levels were measured by enzyme-linked immunosorbent assay. Results Serum apelin levels were significantly higher in type 1 and type 2 diabetic patients than in controls ( P < 0·0001). Serum apelin levels were higher in type 1 than in type 2 diabetic patients ( P = 0·02). In multivariate analysis, serum apelin levels were higher in patients with type 1 diabetes and in patients with type 2 diabetes versus controls. We found a negative correlation between glycosylated haemoglobin and serum apelin levels in all diabetic patients ( r = −0·17, P = 0·008) and in patients with type 2 diabetes ( r = −0·24 P = 0·01). No correlation was found in type 1 diabetic patients. Conclusion Our study showed that apelin concentrations were increased in diabetic patients. This rise, which was greater in type 1 than in type 2 diabetic patients, suggests that obesity is not the main determinant of plasma apelin levels. The negative correlation with glycosylated haemoglobin in patients with type 2 diabetes could indicate that apelin plays a role in glycaemic balance and even insulin sensitivity.
- Subjects
APELIN; TYPE 1 diabetes; TYPE 2 diabetes; CARBOHYDRATE content of food; ADIPOKINES; ENERGY metabolism regulation; BLOOD serum analysis
- Publication
Clinical Endocrinology, 2014, Vol 81, Issue 5, p696
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/cen.12404