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- Title
Synthesis and antimicrobial activity of mono-and biquaternized derivatives of dipyridylethanes and dipyridylethylenes.
- Authors
Vnutskikh, Zh.; Shklyaev, Yu.; Odegova, T.; Chekryshkin, Yu.; Tolstikov, A.; El’chishcheva, N.; Syropyatov, B.
- Abstract
A series of mono-and biquaternized derivatives of dipyridylethanes and dipyridylethylenes has been synthesized and characterized with respect to antimicrobial activity. The new compounds exhibit structure-dependent antimicrobial action on both Gram-negative ( E. coli) and Gram-positive ( St. aureus) bacterial species. Monoquaternized dipyridylethane and dipyridylethylene derivatives show a higher antimicrobial activity than compounds with two onium nitrogen atoms; derivatives of dipyridylethane are less active than the analogous derivatives of dipyridylethylene. A high antimicrobial activity (MIC ∼ 1 mg/ml) was observed for 1-[N-cetyl-(4-pyridinium)]-2-(4-pyridyl)ethylene.
- Subjects
ETHANES; ETHYLENE; ANTI-infective agents; DRUGS; ONIUM ions; PHARMACEUTICAL chemistry
- Publication
Pharmaceutical Chemistry Journal, 2006, Vol 40, Issue 4, p194
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-006-0090-y