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- Title
INVESTIGATION OF IGF-1/GLP-1 RECEPTOR ACTIVATOR IN INTRACEREBRAL HEMORRHAGE USING AUTOLOGOUS BLOOD INJECTION IN RATS.
- Authors
Ehraz, Siddiqui M.; Sidharth, Mehan
- Abstract
Brain hemorrhage is a bleeding disorder of brain with the release of blood from broken vessels either inside or outside the brain. ICH can be spontaneous, traumatic or non traumatic associated with the vascular anomly (aneurysm/angioma) due to hypertension, traumatic injury, contusion, abrasion, hematoma formation, excoriation and incision which frequently occurs in basal ganglia, pons, thalamus, cerebellum and white mater. In elders it is caused by cerebral amyloid angiopathy and in young mainly caused by arteriovenous malformation. ICH may also be caused due to hematological disorders, leukemia, thrombocytopenia, hemophilia, liver disease. Animal models used are basically collagenase injection model and blood injection model in rats. Complications of the post ICH may involve neuro complications such as rebleeding, hydrocephalous, vasospasm, depression, anxiety, coma followed by behavioral dysfunctions like memory/cognitive, postural imbalance, psychosis etc. We used an amino acid which has been extracted and purified from fenugreek Trigonella foenumgraecum seeds, which is known for its traditional medicinal properties. The neuro complications can be further treated by activation of the drug to the IGF-1/GLP-1 receptor. There are limited target based drug interventions to prevent the root cause of cellular and molecular pathological hallmark of ICH thus the current available drug therapy is designed to provide symptomatic relief in individual patient, therefore we designed the current neuroprotective stratigies of extracted drug on IGF-1/GLP-1 receptor by incorporating the discussed animals models.
- Subjects
CEREBRAL amyloid angiopathy; DRUG receptors; CEREBRAL hemorrhage; ARTERIOVENOUS malformation; DRUG activation; CEREBRAL arteriovenous malformations
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p73
- ISSN
0976-7126
- Publication type
Article