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- Title
THE EFFECT OF ETHANOL EXTRACT AND ETHYL ACETIC FRACTION OF STANDARDISED CHAYOTE SQUASH TO REDUCE BLOOD SUGAR LEVEL AND THE FUNCTION OF PANCREATIC β-CELL OF MALE ALBINO RATS INDUCED BY STZ-NA-HFD.
- Authors
Siahaan, Jekson Martiar; Illyas, Syafruddin; Lindarto, Dharma; Nainggolan, Marline
- Abstract
An impaired pancreatic β-cell function can cause glucotoxicity, measured by the homeostasis model assessment of β-cell function (HOMA-B). Glucotoxicity can be controlled by administering extracts and fractions of plant secondary metabolite compounds that are anti-hyperglycemic and preventing damage to pancreatic β-cells. This study was conducted to evaluate the effect of ethanol extract and ethyl acetate fraction of chayote squash on the function of pancreatic β-cells and the decrease of blood glucose levels. Dry chayote squash was characterized, extracted with ethanol, and fractionated with ethyl acetate. The experimental albino rats were administered with streptozotocin, nicotinamide, and high-fat diets for up to 72 hours. After an increase in blood glucose levels, albino rats were treated with ethanol extract and ethyl acetate fraction by post-test randomized controlled group design for one month. After the treatment, the blood glucose level and insulin level were tested. Homeostasis model assessment of insulin resistance (HOMA-IR) was applied. Simplified characteristics of the chayote squash were following the standards of herbal medicines in Indonesia. Chayote squash ethanol extract had a high total phenolic content, while the ethyl acetate fraction had a high total flavonoid content. Giving ethanol extract at a dose of 100 mg/kg bw could increase insulin secretion and HOMA-B to a higher degree. Meanwhile, ethyl acetate fraction at a dose of 100 mg/kg bw could reduce blood glucose levels. It is concluded that the administration of ethanol extract and ethyl acetate fraction of chayote squash can maintain the function of pancreatic β-cells and lower blood glucose levels.
- Subjects
INDONESIA; BLOOD sugar; ETHYL acetate; SQUASHES; ETHANOL; ALBINOS &; albinism; HIGH-fat diet
- Publication
Rasayan Journal of Chemistry, 2021, Vol 14, Issue 1, p65
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2021.1415973