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- Title
Direct Oxidative Arylation of Aryl CH Bonds with Aryl Boronic Acids via Pd Catalysis Directed by the N, N-Dimethylaminomethyl Group.
- Authors
Zhang, Ji ‐ Cheng; Shi, Jiang ‐ Ling; Wang, Bi ‐ Qin; Hu, Ping; Zhao, Ke ‐ Qing; Shi, Zhang ‐ Jie
- Abstract
Biaryl skeletons were directly constructed via palladium-catalyzed ortho-arylation of N, N-dimethyl benzylamine with aryl boronic acids with high efficiency and high regioselectivity under open-flask conditions. The N,N-dimethylaminomethyl group was first applied as a directing group in such an oxidative coupling. Various substrates proved to be efficient coupling partners, furnishing the corresponding ortho-monoarylated or -diarylated arenes in moderate to good yields under mild conditions.
- Subjects
OXIDATIVE coupling; ARYLATION; BORONIC acid derivatives; PALLADIUM catalyst reactivity; CARBON-hydrogen bonds; DIMETHYLAMINOETHANOL; MONOAMINE oxidase
- Publication
Chemistry - An Asian Journal, 2015, Vol 10, Issue 4, p840
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201403292