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- Title
Brain circuits for pain and its treatment.
- Authors
Mercer Lindsay, Nicole; Chen, Chong; Gilam, Gadi; Mackey, Sean; Scherrer, Grégory
- Abstract
Pain is a multidimensional experience with sensory-discriminative, affective-motivational, and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering for patients with chronic pain, motivating research and drug development efforts to investigate and modulate neural activity in the brain's circuits encoding pain unpleasantness. Here, we review progress in understanding the organization of emotion, motivation, cognition, and descending modulation circuits for pain perception. We describe the molecularly defined neuron types that collectively shape pain multidimensionality and its aversive quality. We also review how pharmacological, stimulation, neurofeedback, surgical, and cognitive-behavioral interventions alter activity in these circuits to relieve chronic pain.
- Subjects
PAIN management; EMOTIONS; CHRONIC pain; COGNITION; DRUG development
- Publication
Science Translational Medicine, 2021, Vol 13, Issue 619, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.abj7360