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- Title
EFFETS DES RECEPTEURS A L' ADENOSINE A1 SUR LA SECONDE FENÊTRE DE CARDIOPROTECTION INDUITE PAR L-NAME CHEZ LE COEUR DE RAT ISOLE/PERFUSE.
- Authors
TRAORE KABINE; HUANG BOXIANG; YAN YUSHENG
- Abstract
Aims: adenosine A1 receptors may be or not a mediator of L-NAME induced myocardial the second window of protection. Materials and methods: three groups of Sprague-Dawley rats (control group = 10, L-NAME group = 10 and DPCPX group = 10) were studied in an isolated /perfused heart model. After excision of the hearts, the hearts have been stabilized in the KH solution for 15 minutes (S15), followed by cardiac ischemic for 60 minutes and the reperfusion during 120 minutes but subdivided into three periods: R1, R60 and R120. Heart rate , left ventricular developed pressure, coronary flow and cardiac troponin I were recorded and analyzed. The injury of cardiac tissue was observed under the electronic microscopy. Results: during the 120 minutes of reperfusion, the hemodynamic parameters were lower in the DPCPX group than that in the L-NAME group (P< 0.05); but, the cardiac troponin I was higher in the DPCPX group than that in the L-NAME group (P< 0.05). End, the injury of myocardial cell in the DPCPX was more serious than that in the L-NAME group. Conclusion: these results indicate that adenosine A1 receptors are involved in L-NAME-induced myocardial the second window of protection. Adenosine A1 receptors may be a mediator of L-NAME-induced myocardial the second window of protection.
- Publication
Mali Médical, 2014, Vol 29, Issue 4, p19
- ISSN
0464-7874
- Publication type
Article