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- Title
Platinum hypersensitivity and desensitization.
- Authors
Shingo Miyamoto; Rika Okada; Kazumichi Ando
- Abstract
Platinum agents are drugs used for various types of cancer. With increased frequency of administration of platinum agents, hypersensitivity reactions appear more frequently, occurring in over 25% of cases from the seventh cycle or second line onward. It then becomes difficult to conduct treatment using these agents. Various approaches have been investigated to address hypersensitivity reactions to platinum agents. Desensitization, which gradually increases the concentration of the anticancer drug considered to be the antigen until the target dosage, has been reported as being particularly effective, with a success rate of 80-100%. The aims of this paper are to present the current findings regarding hypersensitivity reactions to platinum agents and to discuss attempts of using desensitization against hypersensitivity reactions worldwide.
- Publication
Japanese Journal of Clinical Oncology, 2015, Vol 45, Issue 9, p795
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyv081