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- Title
Immunohistochemical Evaluation of Thymidylate Synthase (TS) and p16INK4a in Advanced Colorectal Cancer: Implication of TS Expression in 5-FU-based Adjuvant Chemotherapy.
- Authors
Kamoshida, Shingo; Matsuoka, Hiroshi; Ishikawa, Taro; Maeda, Kotaro; Shimomura, Ryoichi; Inada, Ken-ichi; Tsutsumi, Yutaka
- Abstract
Background: Our previous analyses on the expression of thymidylate synthase (TS) and p16INK4a in colorectal cancer patients administered 5-fluorouracil (5-FU) pre-operatively demonstrated that a high level of TS expression was a predictor of 5-FU resistance, and that the combination of a low level of TS expression and induction of p16INK4a after chemotherapy implicated chemosensitivity. The present study aimed to assess the relationship between the biological behavior of advanced colorectal cancer treated post-operatively by 5-FU-based chemotherapy and the expression of TS and p16INK4a in primary tumors.
- Publication
Japanese Journal of Clinical Oncology, 2004, Vol 34, Issue 10, p594
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyh113