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- Title
Insights into the Excited State Dynamics of Donor–Acceptor Organic Photosensitizer for Precise Deep‐Brain Two‐Photon Photodynamic Therapy.
- Authors
Zhao, Hui; He, Mubin; He, Tingchao; Wu, Zizi; Pan, Yonghui; Gao, Jia; Miao, Xiaofei; Li, Junzi; Ma, Huili; Huang, Wei; Hu, Wenbo; Fan, Quli
- Abstract
Organic photosensitizer with both large two‐photon absorption (σ) and efficient intersystem crossing (ISC) offers incomparable advantages in precise two‐photon photodynamic therapy. However, the current design strategy cannot achieve efficient ISC without compromising σ. Here, very efficient ISC and ultrahigh σ in organic photosensitizer (PFBT) for precise cerebrovascular two‐photon photodynamic therapy is simultaneously achieved. A hybridized local and charge‐transfer (1HLCT) excited state in PFBT, formed by incorporating benzothiadiazole into a typical polyfluorene (PF), is the key to initiating efficient ISC while bringing substantial σ enhancement (25 000 GM vs 10 000 GM) compared to PF. Mechanism studies identify that 1HLCT produces large spin‐orbit coupling and tiny singlet‐triplet energy gaps, together generating efficient ISC. These properties afford PFBT nanophotosensitizer a ≈2000‐fold increase in two‐photon photodynamic therapy efficiency than clinically‐used Photofrin, enabling in vivo deep‐brain cerebrovascular imaging and closure with unprecedented precision.
- Subjects
PHOTODYNAMIC therapy; EXCITED states; PHOTOSENSITIZERS; SPIN-orbit interactions; BAND gaps
- Publication
Laser & Photonics Reviews, 2024, Vol 18, Issue 5, p1
- ISSN
1863-8880
- Publication type
Article
- DOI
10.1002/lpor.202300917