We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bio‐based α,ω‐Functionalized Hydrocarbons from Multi‐step Reaction Sequences with Bio‐ and Metallo‐catalysts Based on the Fatty Acid Decarboxylase OleT<sub>JE</sub>.
- Authors
Bojarra, Samiro; Grote, Marius; Baraibar, Álvaro Gómez; Mügge, Carolin; Reichert, Dennis; Kourist, Robert; Dennig, Alexander; Nidetzky, Bernd
- Abstract
Abstract: OleT from <italic>Jeotgalicoccus</italic> sp. ATCC 8456 catalyzes the decarboxylation of ω‐functionalized fatty acids to the corresponding alkenols, which can themselves serve as starting material for the synthesis of polymers and fine chemicals. To show the versatility of possible reactions, a series of in vitro reaction cascades was developed where an alkenol produced by the decarboxylation of ω‐hydroxy fatty acids can be further converted into alkenylamines and diols. By coupling OleT with an alcohol dehydrogenase or alcohol oxidase as well as an amino‐transaminase, an oxidative decarboxylation followed by the oxidation of the terminal alcohol and a subsequent reductive transamination could be carried out. By using different cofactors or electron sources, the reactions could be performed sequentially or simultaneously. The combination of enzymatic decarboxylation with a ruthenium catalyst in a chemo‐enzymatic cascade provides a novel way to synthesize long‐chain diols.
- Subjects
DECARBOXYLATION; FATTY acids; ENOLS; POLYMERS; GLYCOLS; ALCOHOL dehydrogenase; ALCOHOL oxidase; RUTHENIUM catalysts
- Publication
ChemCatChem, 2018, Vol 10, Issue 5, p1192
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.201701804