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- Title
The Genome of Haemoproteus tartakovskyi and Its Relationship to Human Malaria Parasites.
- Authors
Bensch, Staffan; Canbäck, Björn; DeBarry, Jeremy D.; Johansson, Tomas; Hellgren, Olof; Kissinger, Jessica C.; Palinauskas, Vaidas; Videvall, Elin; Valkiūnas, Gediminas
- Abstract
The phylogenetic relationships among hemosporidian parasites, including the origin of Plasmodium falciparum, themost virulent malaria parasite of humans, have been heavily debated for decades. Studies based on multiple-gene sequences have helped settle many of these controversial phylogenetic issues. However, denser taxon sampling and genome-wide analyses are needed to confidently resolve the evolutionay relationships among hemosporidian parasites. Genome sequences of several Plasmodium parasites are available but only for species infecting primates and rodents. To root the phylogenetic tree of Plasmodium, genomic data from related parasites of birds or reptiles are required. Here, we use a novel approach to isolate parasite DNA from microgametes and describe the first genome of a bird parasite in the sister genus to Plasmodium, Haemoproteus tartakovskyi. Similar to Plasmodium parasites, H. tartakovskyi has asmall genome (23.2Mb, 5,990 genes) and aGCcontent (25.4%) closer to P. falciparum (19.3%) than to Plasmodium vivax (42.3%). Combined with novel transcriptome sequences of the bird parasite Plasmodium ashfordi, our phylogenomic analyses of 1,302 orthologous genes demonstrate that mammalian-infecting malaria parasites are monophyletic, thus rejecting the repeatedly proposedhypothesis that the ancestorof Laverania parasitesoriginated froma secondary host shiftfrombirds to humans.Genes and genomic features previously found to be shared between P. falciparum and birdmalaria parasites, but absent in other mammal malaria parasites, are therefore signatures of maintained ancestral states. We foresee that the genome of H. tartakovskyi will open new directions for comparative evolutionary analyses of malarial adaptive traits.
- Subjects
GENOMES; PHYLOGENY; PLASMODIUM falciparum; PLASMODIUM; PARASITES; PLASMODIIDAE
- Publication
Genome Biology & Evolution, 2016, Vol 8, Issue 5, p1361
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evw081