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- Title
Confirmación de dexametasona y diclofenaco por LC-MS-MS como adulterantes en un producto herbolario.
- Authors
Garza-Ocañas, Lourdes; Badillo-Castañeda, Christian Tadeo; Montoya-Eguía, Sandra Lucía; Saenz-Chávez, Pedro Lennon; Garza-Ulloa, Humberto
- Abstract
Objective. To confirm the presence of dexamethasone and diclofenac as adulterants of an herbal product. Materials and methods. For identificaction and confirmation of drugs a method of instrumental analysis by liquid chromatography coupled with high pressure tandem mass spectrometry was used. Results. The presence of dexamethasone and diclofenac was confirmed in samples of 11 bottles of Reumofan Plus obtained from patients and/or physicians. The methodology used, allowed separation of stereoisomers dexamethasone and betamethasone, the relative abundances of product ions 237.2 and 279.2 m / z spectrally differentiate the compounds. Conclusions. The presence of dexamethasone and diclofenac was confirmed in samples of a product marketed as "100% natural" obtained from patients and / or physicians in a period from January to December, 2011.
- Publication
Salud Pública de México, 2013, Vol 55, Issue 5, p498
- ISSN
0036-3634
- Publication type
Article
- DOI
10.21149/spm.v55i5.7250