We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neuroprotective Effects of Quercetin, Lycium Barbarum and Chitosan Against of the Oxidative Stress Induced by Exposure to Hypobaric Hypoxia.
- Authors
Anca, DUMITROVICI; BOLFA, Pompei F.; BORZA, Gabriel; MUREŞAN, Adriana; MAIER, Monica; VLAD, Delia; CHIŞ, Irina Camelia
- Abstract
The purpose of this study was to observe, highlight and quantify the neuroprotective effects of these natural antioxidants' administration. Chronic and acute exposure to hypobaric hypoxia (HH) induces changes of the pro-oxidant/antioxidant balance in the brain and throughout the body. It has been shown that natural antioxidants supplementation (Quercetin, Lycium barbarum and Chitosan) is effective in preventing the hypoxic stress. The present study was conducted on male, Wistar rats, exposed to acute and chronic hypobaric hypoxia (5500 m, 23h/day) for different periods of time (1 or 14 days) or kept in normoxia for 14 days. Some of the rats were administered natural antioxidants one day before the first HH exposure and 14 days before and prior to every hypoxic exposure for the next 14 days. At the end of the study the animals were euthanized and the brains were harvested and stored for further analysis. Brain sections were obtained and examined histopathologically to determine the number of neurons in necrosis/apoptosis. The results show a negative effect of chronic hypobaric hypoxia on the neurons viability and neuroprotective effects of natural antioxidants' administration. This study suggests that the treatment with Quercetin, Lycium barbarum or Chitosan alone substantially ameliorated induced brain dysfunction and acts like a neuroprotectant.
- Subjects
ANTIOXIDANTS; HYPOXEMIA; LABORATORY rats; HISTOPATHOLOGY; NEURONS; CHITOSAN
- Publication
Bulletin of the University of Agricultural Sciences & Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 2013, Vol 70, Issue 1, p47
- ISSN
1843-5270
- Publication type
Article