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- Title
The Effect of Zinc Oxide Nanoparticles on Properties and Burn Wound Healing Activity of Thixotropic Xymedone Gels.
- Authors
Sheferov, Ilya; Balakireva, Alyona; Panteleev, Dmitry; Spitskaya, Irina; Orekhov, Sergey; Kazantsev, Oleg; Solovyeva, Anna; Novopoltsev, Denis; Melnikova, Nina
- Abstract
Zinc oxide nanoparticles (ZnO NPs) modified by oxopyrymidine alcohol, also known as xymedone (Xym), were obtained and studied using FTIR, UV-vis, and fluorescent spectroscopy, and SEM, BET, powder XRD, and DLS analysis. A formulation of thixotropic hydrophilic gels containing Carbopol-based Xym and ZnO NPs was developed. A vertical Franz cell with a cellulose acetate membrane was used as a model to investigate the passive diffusion of the gel components by AAS. The gel components—Xym and ZnO NPs—were shown to penetrate through acetyl cellulose membrane within 5–7 h depending on an initial amount, and its values were in the range of 56–77%. The penetration of modified ZnO NPs by Xym was more effective in contrast to ZnO NPs without modification. The burn wound healing activity of ZnO NPs–Xym gel was demonstrated on a thermal burn wound model on rats. SOD and GR activity was increased by 30–35% during ZnO NPs–Xym gel treatment, the burn area on 10 postburn day decreased by 10% in contrast to a positive control, Methyluracyl®® ointment.
- Subjects
THIXOTROPIC gels; ZINC oxide; CELLULOSE acetate; NANOPARTICLES; HEALING
- Publication
Scientia Pharmaceutica, 2022, Vol 90, Issue 4, p61
- ISSN
0036-8709
- Publication type
Article
- DOI
10.3390/scipharm90040061