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- Title
Investigation of polymorphisms in BMP2, BMP4, SMAD6 and RUNX2 genes and pulp stones.
- Authors
Thuller, Katherine Azevedo Batistela Rodrigues; Antunes, Lívia Azeredo Alves; Kublitski, Prescila Mota de Oliveira; Brancher, João Armando; Baratto‐Filho, Flares; Küchler, Erika Calvano; Silva‐Sousa, Alice Corrêa; Sousa‐Neto, Manoel Damião; Gabardo, Marilisa Carneiro Leão; Antunes, Leonardo Santos
- Abstract
This study aimed to assess the association between genetic polymorphisms in BMP2 (rs1005464 and rs235768), BMP4 (rs17563), SMAD6 (rs2119261 and rs3934908) and RUNX2 (rs59983488 and rs1200425) and pulp stones (PS). A total of 117 participants, consisting of 63 individuals with PS and 54 without PS, were included. Digital radiographs and a demographic/clinical questionnaire were used. Genomic DNA from salivary cells was genotyped via real‐time polymerase chain reaction. Statistical analyses, including Chi‐Square, Fisher's exact tests, Poisson regression and dimensionality reduction, were conducted. The rs2119261 polymorphism in the SMAD6 gene showed an association with genotype distribution in the recessive model (p = 0.049). The T–T haplotype in the SMAD6 gene (rs2119261 and rs3934908) was more prevalent in the control group and significantly linked with PS (p = 0.029). No associations were found between PS risk and genetic polymorphisms in BMP2, BMP4 and RUNX2. Polymorphisms in the SMAD6 gene were associated with PS.
- Subjects
GENETIC polymorphisms; DENTAL pulp; FISHER exact test; POISSON regression; POLYMERASE chain reaction
- Publication
Australian Endodontic Journal, 2024, Vol 50, Issue 2, p299
- ISSN
1329-1947
- Publication type
Article
- DOI
10.1111/aej.12835