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- Title
Neonates with Culture Proven Sepsis Have Lower Amounts and Percentage of CD45RA+ T Cells.
- Authors
A. Aygun; A. Citak Kurt; Ahmet Godekmerdan; Abdullah Kurt; Saadet Akarsu; M. Gurgoze; Erdal Yilmaz
- Abstract
Abstract To evaluate the expression of lymphocyte subsets in newborns diagnosed as culture proven or culture negative sepsis and to investigate the differentiation. The aim of this study is to explore neonatal immunology in newborns diagnosed as culture proven or culture negative neonatal sepsis and to identify their place in the diagnosis. This prospective study was performed in newborns who were diagnosed as neonatal sepsis and hospitalized in a tertiary care hospital and who were classified as culture proven sepsis (n = 12), as culture negative sepsis (n = 21) and healthy (n = 17). Lymphocyte subsets were obtained at time of diagnosis. Culture proven sepsis had statistically significant increase of WBC compared to culture negative sepsis and control groups (p p + was lower in culture proven sepsis and absolute count of CD4+ was lower in culture negative sepsis (p + were lower in culture negative sepsis than control and percentage of CD45RA+ was lower in culture proven sepsis than control (p + was higher in culture proven sepsis than control group (p
- Subjects
SEPSIS; CD4 antigen; T cells; NEWBORN infants; LYMPHOCYTES; IMMUNOLOGY
- Publication
Inflammation, 2008, Vol 31, Issue 4, p222
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-008-9068-0