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- Title
Pre‐emptive administration of gabapentinoids to reduce postoperative pain and opioid usage following oral and maxillofacial surgical procedures.
- Authors
Bhavaraju, Surya A.; Vorrasi, John S.; Talluri, Sandeep; Kalladka, Mythili; Khan, Junad
- Abstract
Aim: The objective of this review was to assess the efficiency of pre‐emptive gabapentinoid administration on postoperative pain and opioid consumption in patients undergoing oral surgical procedures. Material and Methods: A review of the literature was performed using various indexed databases. A total of six randomized controlled trials (RCTs) were included in the current systematic review which compared postoperative analgesic and/or opioid‐sparing effect of gabapentinoids (either alone or in combination with other drugs). Results: Out of the six studies included, four studies showed a statistically significant reduction in pain scores while three studies showed a significant reduction in opioid consumption postoperatively. All studies included reported that adverse effects like nausea and vomiting were higher in the placebo group except for one study, which reported a higher frequency of adverse events in the pregabalin group. The overall risk of bias was low in five studies and moderate in one study. Conclusions: In brief, gabapentinoids when administered pre‐emptively in patients undergoing oral surgical procedures reduced postoperative pain and opioid consumption. However, there is a need for further research to come to a consensus regarding the dosage and timing of the pre‐emptive gabapentinoids administration. Also, surgery specific research is needed in future studies.
- Subjects
POSTOPERATIVE pain; OPERATIVE surgery; OPIOIDS; PAIN management; ORAL surgery
- Publication
Oral Surgery (1752-2471), 2022, Vol 15, Issue 1, p106
- ISSN
1752-2471
- Publication type
Article
- DOI
10.1111/ors.12617