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- Title
A New Multi-Mode Perfusion System for <italic>Ex Vivo</italic> Heart Perfusion Study.
- Authors
Xin, Liming; Gellner, Bryan; Ribeiro, Roberto Vanin Pinto; Ruggeri, Giulia Maria; Banner, David; Meineri, Massimiliano; Rao, Vivek; Zu, Jean; Badiwala, Mitesh V.
- Abstract
<italic>Ex vivo</italic> heart perfusion has been shown to be an effective means of facilitating the resuscitation and assessment of donor hearts for cardiac transplantation. Over the last ten years however, only a few <italic>ex vivo</italic> perfusion systems have been developed for this application. While results have been promising, a system capable of facilitating multiple perfusion strategies on the same platform has not yet been realized. In this paper, the design, development and testing of a novel and modular <italic>ex vivo</italic> perfusion system is described. The system is capable of operating in three unique primary modes: the traditional Langendorff Mode, Pump-Supported Working-Mode, and Passive Afterload Working-Mode. In each mode, physiological hemodynamic parameters can be produced by managing perfusion settings. To evaluate heart viability, six experiments were conducted using porcine hearts and measuring several parameters including: pH, aortic pressure, lactate metabolism, coronary vascular resistance (CVR), and myocardial oxygen consumption. Pressure-volume relationship measurements were used to assess left ventricular contractility in each Working Mode. Hemodynamic and metabolic conditions remained stable and consistent across 4 h of <italic>ex vivo</italic> heart perfusion on the <italic>ex vivo</italic> perfusion system, validating the system as a viable platform for future development of novel preservation and assessment strategies.
- Subjects
ARTIFICIAL blood circulation; ANIMAL experimentation; ECHOCARDIOGRAPHY; EXPERIMENTAL design; HEART transplantation; HEMODYNAMICS; PERFUSION; SWINE; DATA analysis software; EQUIPMENT &; supplies
- Publication
Journal of Medical Systems, 2018, Vol 42, Issue 2, p0
- ISSN
0148-5598
- Publication type
Article
- DOI
10.1007/s10916-017-0882-5