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- Title
Resistance Exercise Reduces Body Fat and Insulin During Androgen-Deprivation Therapy for Prostate Cancer.
- Authors
Winters-Stone, Kerri M.; Dieckmann, Nathan; Maddalozzo, Gianni F.; Bennett, Jill A.; Ryan, Christopher W.; Beer, Tomasz M.
- Abstract
Purpose/Objectives: To determine whether exercise could reduce biomarkers of cancer progression in prostate cancer survivors (PCSs) on androgen-deprivation therapy (ADT). Design: Randomized, controlled trial. Setting: Oregon Health and Science University School of Nursing. Sample: 51 PCSs randomized to one year of resistance and impact training or a stretching control group. Methods: The authors investigated changes in body composition and cancer-related biomarkers, and the influence of age and fat loss on changes in biomarkers. Main Research Variables: Body composition (total fat, trunk fat, and lean mass), insulin, insulin-like growth factor-1, and sex hormone-binding globulin. Findings: In the 36 PCSs with baseline and 12-month data, total fat (p = 0.02) and trunk fat (p = 0.06) mass decreased in the training group compared to gains In controls. Loss of total and trunk fat each mediated the relationship between groups and one-year change in insulin (p < 0.05). Age moderated the insulin response to exercise where insulin reductions were smaller with increasing age (p = 0.03). Conclusions: Resistance and impact exercise may reduce body fat among PCSs undergoing ADT, in turn exerting an insulin-lowering effect. Implications for Nursing: Nurses should counsel PCSs to exercise to reduce the risk of obesity and associated conditions, including cancer progression.
- Subjects
OREGON; ANTIANDROGENS; ANALYSIS of covariance; BODY composition; CONFIDENCE intervals; STATISTICAL correlation; EXERCISE; INSULIN; LONGITUDINAL method; PROSTATE tumors; QUESTIONNAIRES; SELF-evaluation; TUMOR markers; SAMPLE size (Statistics); RANDOMIZED controlled trials; BLIND experiment; DESCRIPTIVE statistics; PHOTON absorptiometry; RESISTANCE training; THERAPEUTICS
- Publication
Oncology Nursing Forum, 2015, Vol 42, Issue 4, p348
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/15.ONF.348-356