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- Title
Home Screening for Bacterial Vaginosis to Prevent Sexually Transmitted Diseases.
- Authors
Schwebke, Jane R.; Lee, Jeannette Y.; Lensing, Shelly; Philip, Susan S.; Wiesenfeld, Harold C.; Seña, Arlene C.; Trainor, Nikole; Acevado, Nincoshka; Saylor, Lisa; Rompalo, Ann M.; Cook, Robert L.
- Abstract
Background. Longitudinal studies have consistently found a significant association between bacterial vaginosis (BV) and acquisition of sexually transmitted diseases. However, there are limited prospective data to confirm these findings. Methods. We conducted a prospective, randomized, open-label trial of home screening and treatment of young women with asymptomatic BV who were also at high risk for sexually transmitted diseases. These women were screened every 2 months for 12 months and randomized to treatment with oral metronidazole 500 mg twice daily for 7 days or observation alone. The primary outcome was the incidence of gonorrhea and/or chlamydia. Results. A total of 1365 subjects were enrolled in the study across 10 sites. Adherence with mailing specimens obtained at home was excellent in both groups (84%-88%). The incidence of gonorrhea and/or chlamydia was 19.1 per 100 person-years (95% confidence interval, 15.1-22.1) for the treatment group and 18.5 per 100 person-years (15.1-22.8) for the observation arm, a difference that was not statistically significant. Conclusions. Young women were very amenable to home screening for BV, gonorrhea, and chlamydia. Treatment of asymptomatic BV with 1 week of oral metronidazole did not decrease the incidence of gonorrhea and/or chlamydia.
- Subjects
HOME care services; PREVENTION of sexually transmitted diseases; BACTERIAL vaginitis; MEDICAL screening; RANDOMIZED controlled trials; METRONIDAZOLE; GONORRHEA; CHLAMYDIA infections
- Publication
Clinical Infectious Diseases, 2016, Vol 62, Issue 5, p531
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/civ975