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- Title
Conversion to dementia in mild cognitive impairment diagnosed with DSM-5 criteria and with Petersen's criteria.
- Authors
Marcos, G.; Santabárbara, J.; Lopez‐Anton, R.; De‐la‐Cámara, C.; Gracia‐García, P.; Lobo, E.; Pírez, G.; Menchón, J. M.; Palomo, T.; Stephan, B. C. M.; Brayne, C.; Lobo, A.
- Abstract
Objective In a background of revision of criteria for states of increased risk for progression to dementia, we compare the conversion rate to dementia and Alzheimer's disease ( AD) of mild cognitive impairment ( MCI) as diagnosed using DSM-5 ( DSM-5- MCI) and Petersen's (P- MCI) criteria. Method A population representative cohort of 4057 dementia-free individuals 55+ years of age was followed up at 2.5 and 4.5 years in Zaragoza, Spain ( ZARADEMP). Using the Geriatric Mental State- AGECAT for assessment, research psychiatrists diagnosed DSM-5- MCI and P- MCI following operationalized criteria. 'Conversion rate' ( CR), 'annual conversion rate' ( ACR), and incidence rate ( IR) were calculated along with incidence rate ratio ( IRR) to compare the performance of the intermediate cognitive definitions. Results At 4.5-year follow-up, in individuals aged 65+ years, ACRs for non-cases, P- MCI, and DSM-5- MCI were 0.8, 1.9 and 3.4, respectively, for global dementia. The IRRs were 2.9 and 5.3 for P- MCI and DSM5- MCI, respectively, being the non-cases the reference category. The corresponding values were slightly lower for AD. Conclusion Conversion rate to dementia and AD was higher using DSM-5- MCI criteria than using Petersen's criteria. However, prediction of the construct still has some way to go, as most MCI individuals did not convert at 4.5-year follow-up.
- Subjects
DEMENTIA risk factors; MILD cognitive impairment; GERIATRIC psychiatry; CONVERSION disorder; MENTAL health of older people; DIAGNOSIS
- Publication
Acta Psychiatrica Scandinavica, 2016, Vol 133, Issue 5, p378
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/acps.12543