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- Title
Asymmetric dimethylarginine correlates with indicators of prethrombotic state in patients with nonvalvular atrial fibrillation.
- Authors
Du, Zhaona; Jiang, Wenbo; Yu, Chengyun; Zhang, Ming; Xia, Wei
- Abstract
Objective: The mechanism of asymmetric dimethylarginine (ADMA) in thrombosis in patients with nonvalvular atrial fibrillation (NVAF) is still unclear. Our aim was to investigate the relationship between ADMA and indicators of prethrombotic state in NVAF patients and to analyze the predictive role of ADMA in NVAF thrombosis. Methods: A total of 192 NVAF patients were continuously selected from January 2023 to October 2023. Plasma ADMA levels were measured by high‐performance liquid chromatography. P‐selectin (P‐sel), von Willebrand factor (vWF), D‐dimer (D‐D), and plasminogen activator inhibitor‐1 (PAI‐1) levels were measured by enzyme‐linked immunosorbent assay (ELISA). Nitric oxide (NO) levels were measured by the nitrate reductase assay for plasma nitrite/nitrate, then the Griess method (Shanghai Hailian Biotechnology Co., Shanghai, China) was used to calculate plasma NO levels. Results: In our study, ADMA levels were significantly elevated and positively correlated with P‐sel, vWF, D‐D, and PAI‐1, whereas NO levels were significantly negatively correlated with these prethrombotic factors in NVAF. Furthermore, multifactorial logistic regression analysis showed that ADMA and LA diameter were independent predictors of high thrombosis risk (CHA2DS2‐VASc ≥2 score) in patients with NVAF. Conclusions: Our findings suggested that ADMA correlated with the prethrombotic state in NVAF and that reduction of ADMA levels in NVAF patients may be a novel therapeutic strategy for thrombosis risk reduction.
- Subjects
THROMBOSIS risk factors; ARGININE; HIGH performance liquid chromatography; PEARSON correlation (Statistics); NITRIC oxide; T-test (Statistics); DATA analysis; RESEARCH funding; ENZYME-linked immunosorbent assay; LOGISTIC regression analysis; FIBRIN fibrinogen degradation products; MULTIVARIATE analysis; MANN Whitney U Test; CHI-squared test; EXPERIMENTAL design; ANTIGENS; BLOOD coagulation factors; ATRIAL fibrillation; PLASMINOGEN activators; NITRITES; STATISTICS; DATA analysis software
- Publication
Pacing & Clinical Electrophysiology, 2024, Vol 47, Issue 6, p838
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/pace.14952