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- Title
Pharmacokinetic Properties of <sup>99m</sup>Tc-PSMA: A New Radiopharmaceutical for SPECT Imaging of Prostate Cancer.
- Authors
Tishchenko, V. K.; Vlasova, O. P.; Ivannikov, A. I.; Dorovatovskiy, S. A.; Pankratov, A. A.; Morozova, N. B.; Fedorova, A. V.; Lebedeva, A. A.; Kuzenkova, K. A.; Stepchenkova, E. D.; Khailov, A. M.; Shegai, P. V.; Ivanov, S. A.; Kaprin, A. D.
- Abstract
Prostate-specific membrane antigen (PSMA), which is overexpressed in advanced prostate cancer, is a well-established target for the development of antitumor diagnostic and therapeutic radiopharmaceuticals. The aim of this work is the preclinical study of the pharmacokinetics of a new radiopharmaceutical 99mTc-PSMA. Tumor uptake of 99mTc-PSMA is 1.81–3.91%/g with a maximum uptake of 3.91 ± 0.35%/g at 3 h of post-injection. The highest uptake (up to 140.11%/g) of 99mTc-PSMA throughout the study was observed in the kidneys. Tumor uptake of 99mTc-PSMA was higher than in other organs and tissues, except the kidneys
- Subjects
PROSTATE cancer; RADIOPHARMACEUTICALS; PHARMACOKINETICS
- Publication
Physics of Atomic Nuclei, 2023, Vol 86, Issue 11, p2513
- ISSN
1063-7788
- Publication type
Article
- DOI
10.1134/S1063778823110455