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- Title
Hypoxia activates a background conductance in freshly isolated pulmonary arterial endothelial cells of the rat
- Authors
Hogg, Dayle S.; Kozlowski, Roland Z.
- Abstract
Utilising the patch-clamp recording technique we have demonstrated for the first time the effects of hypoxia on the background current in pulmonary arterial endothelial cells. Electrophysiological studies revealed the presence of a novel oxygen-sensitive, non-selective cation conductance (INSC) in these cells. The inward component of INSC was significantly potentiated by hypoxia. Both the inward and outward components of INSC were inhibited by both La3+ and Gd3+. Hypoxic activation of INSC may provide an important Ca2+ influx pathway essential for the release of a pulmonary-selective vasoconstrictor pivotal to the sustained phase of hypoxic pulmonary vasoconstriction.
- Subjects
HYPOXEMIA; ELECTROPHYSIOLOGY
- Publication
FEBS Letters, 2002, Vol 522, Issue 1-3, p125
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02912-5