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- Title
New insights into cortico-basal-cerebellar connectome: clinical and physiological considerations.
- Authors
Quartarone, Angelo; Cacciola, Alberto; Milardi, Demetrio; Ghilardi, Maria Felice; Calamuneri, Alessandro; Chillemi, Gaetana; Anastasi, Giuseppe; Rothwell, John
- Abstract
The current model of the basal ganglia system based on the 'direct', 'indirect' and 'hyperdirect' pathways provides striking predictions about basal ganglia function that have been used to develop deep brain stimulation approaches for Parkinson's disease and dystonia. The aim of this review is to challenge this scheme in light of new tract tracing information that has recently become available from the human brain using MRI-based tractography, thus providing a novel perspective on the basal ganglia system. We also explore the implications of additional direct pathways running from cortex to basal ganglia and between basal ganglia and cerebellum in the pathophysiology of movement disorders.
- Subjects
DEEP brain stimulation; BASAL ganglia; PARKINSON'S disease; MOVEMENT disorders
- Publication
Brain: A Journal of Neurology, 2020, Vol 143, Issue 2, p396
- ISSN
0006-8950
- Publication type
journal article
- DOI
10.1093/brain/awz310