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- Title
Enteric Protein Loss during Shigellosis.
- Authors
Bennish, Michael L.; Salam, Mohammed A.; Wahed, Mohammed A.
- Abstract
To determine whether protein-losing enteropathy occurs during shigellosis, we measured concentrations of α1-antitrypsin in sequential stool samples from 110 adults hospitalized with acute dysentery due to <em>Shigella</em> infection. Mean stool concentrations of α1-antitrypsin on admission were 10.9 MS/mg dry weight of stool. Stool α1-antitrypsin concentrations were significantly (<em>p</em> < 0.001) lower on the 3rd and 5th study days (4.1 and 2.2 µg/mg, respectively) than on admission. Admission mean α1-antitrypsin concentrations in patients with <em>Shigella dysentenae</em> type 1 infection (14.4 µg/mg) were significantly (<em>p</em> < 0.05) higher than in patients infected with other species of <em>Shigella</em> (9.3 µg/mg)-Stool α1-antitrypsin concentrations were significantly correlated with the number of erythrocytes in the stool, and inversely correlated with serum protein concentration. Patients in whom antimicrobial treatment failed, most often because they were infected with a resistant strain of <em>Shigella</em>, had significantly higher concentrations of α1-antitrypsin on all three study days. We conclude that <em>Shigella</em> infection is associated with a protein-losing onteropathy, that this enteropathy is more severe with <em>S. dysenteriae</em> type 1 infection, and that the enteropathy improves with appropriate antimicrobial therapy.
- Subjects
PROTEIN-losing enteropathy; SHIGELLOSIS; ALPHA 1-antitrypsin; FECES examination; ANTI-infective agents
- Publication
American Journal of Gastroenterology (Springer Nature), 1993, Vol 88, Issue 1, p53
- ISSN
0002-9270
- Publication type
Article