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- Title
Heritability and molecular genetic basis of acoustic startle eye blink and affectively modulated startle response: A genome-wide association study.
- Authors
Vaidyanathan, Uma; Malone, Stephen M.; Miller, Michael B.; McGue, Matt; Iacono, William G.
- Abstract
Acoustic startle responses have been studied extensively in relation to individual differences and psychopathology. We examined three indices of the blink response in a picture-viewing paradigm-overall startle magnitude across all picture types, and aversive and pleasant modulation scores-in 3,323 twins and parents. Biometric models and molecular genetic analyses showed that half the variance in overall startle was due to additive genetic effects. No single nucleotide polymorphism was genome-wide significant, but GRIK3 produced a significant effect when examined as part of a candidate gene set. In contrast, emotion modulation scores showed little evidence of heritability in either biometric or molecular genetic analyses. However, in a genome-wide scan, PARP14 produced a significant effect for aversive modulation. We conclude that, although overall startle retains potential as an endophenotype, emotion-modulated startle does not.
- Subjects
BLINKING (Physiology); MOLECULAR genetics; HERITABILITY; STARTLE reaction; PSYCHOPHYSIOLOGY &; genetics; SINGLE nucleotide polymorphisms
- Publication
Psychophysiology, 2014, Vol 51, Issue 12, p1285
- ISSN
0048-5772
- Publication type
Article
- DOI
10.1111/psyp.12348