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- Title
Periprosthetic osteolysis: genetics, mechanisms and potential therapeutic interventions.
- Authors
Noordin S; Masri B; Noordin, Shahryar; Masri, Bassam
- Abstract
Aseptic loosening and periprosthetic osteolysis occur as a result of the biological response to particulate wear debris and are one of the leading causes of arthroplasty failure. Periprosthetic osteolysis originates from chronic inflammatory responses triggered by implant-derived particulate debris, which cause recruitment of cells, including macrophages, fibroblasts, lymphocytes and osteoclasts. These cells secrete proinflammatory and osteoclastogenic cytokines, exacerbating the inflammatory response. In addition to their direct activation by phagocytosis, there are contributing autocrine and paracrine effects that create a complex milieu within the periprosthetic space, which ultimately governs the development of osteolysis. Chronic cell activation may upset the delicate balance between bone formation and bone resorption leading to periprosthetic osteolysis. This article summarizes the genetic mechanisms underlying periprosthetic loosening and identifies potential therapeutic agents.
- Publication
Canadian Journal of Surgery, 2012, Vol 55, Issue 6, p408
- ISSN
0008-428X
- Publication type
journal article
- DOI
10.1503/cjs.003711