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- Title
Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles.
- Authors
Pitarresi, Giovanna; Barberi, Giuseppe; Palumbo, Fabio Salvatore; Schillaci, Domenico; Fiorica, Calogero; Catania, Valentina; Indelicato, Serena; Bongiorno, David; Biscari, Giuseppina; Giammona, Gaetano
- Abstract
The development of biomedical systems with antimicrobial and antibiofilm properties is a difficult medical task for preventing bacterial adhesion and growth on implanted devices. In this work, a fibrillar scaffold was produced by electrospinning a polymeric organic dispersion of polylactic acid (PLA) and poly(α,β-(N-(3,4-dihydroxyphenethyl)-L-aspartamide-co-α,β-N-(2-hydroxyethyl)-L-aspartamide) (PDAEA). The pendant catechol groups of PDAEA were used to reduce silver ions in situ and produce silver nanoparticles onto the surface of the electrospun fibers through a simple and reproducible procedure. The morphological and physicochemical characterization of the obtained scaffolds were studied and compared with virgin PLA electrospun sample. Antibiofilm properties against Pseudomonas aeruginosa, used as a biofilm-forming pathogen model, were also studied on planar and tubular scaffolds. These last were fabricated as a proof of concept to demonstrate the possibility to obtain antimicrobial devices with different shape and dimension potentially useful for different biomedical applications. The results suggest a promising approach for the development of antimicrobial and antibiofilm scaffolds.
- Subjects
METAL scaffolding; BACTERIAL adhesion; ARTIFICIAL implants; PSEUDOMONAS aeruginosa; SILVER ions; SILVER nanoparticles; POLYLACTIC acid
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 23, p15378
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232315378