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- Title
What Do We Know about Classical and Non-Classical Progesterone Receptors in the Human Female Reproductive Tract? A Review.
- Authors
Medina-Laver, Yassmin; Rodríguez-Varela, Cristina; Salsano, Stefania; Labarta, Elena; Domínguez, Francisco
- Abstract
The progesterone hormone regulates the human menstrual cycle, pregnancy, and parturition by its action via the different progesterone receptors and signaling pathways in the female reproductive tract. Progesterone actions can be exerted through classical and non-classical receptors, or even a combination of both. The former are nuclear receptors whose activation leads to transcriptional activity regulation and thus in turn leads to slower but long-lasting responses. The latter are composed of progesterone receptors membrane components (PGRMC) and membrane progestin receptors (mPRs). These receptors rapidly activate the appropriate intracellular signal transduction pathways, and they can subsequently initiate specific cell responses or even modulate genomic cell responses. This review covers our current knowledge on the mechanisms of action and the relevance of classical and non-classical progesterone receptors in female reproductive tissues ranging from the ovary and uterus to the cervix, and it exposes their crucial role in female infertility.
- Subjects
GENITALIA; CELLULAR signal transduction; PROGESTERONE receptors; FEMALE infertility; CERVIX uteri; FEMALE reproductive organs; MENSTRUAL cycle
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 20, p11278
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms222011278