We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mast Cells May Regulate The Anti-Inflammatory Activity of IL-37.
- Authors
Theoharides, Theoharis C.; Tsilioni, Irene; Conti, Pio
- Abstract
Mast cells are unique immune cells involved in allergic reactions, but also in immunity and inflammation. Interleukin 37 (IL-37) has emerged as an important regulatory cytokine with ability to inhibit immune and inflammatory processes. IL-37 is made primarily by macrophages upon activation of toll-like receptors (TLR) leading to generation of mature IL-37 via the action of caspase 1. In this review, we advance the premise that mast cells could regulate the anti-inflammatory activity of the IL-37 via their secretion of heparin and tryptase. Extracellular IL-37 could either dimerize in the presence of heparin and lose biological activity, or be acted upon by proteases that can generate even more biologically active IL-37 forms. Molecules that could selectively inhibit the secretion of mast cell mediators may, therefore, be used together with IL-37 as novel therapeutic agents.
- Subjects
INTERLEUKIN-37; MAST cells; MACROPHAGE activation; HEPARIN; TOLL-like receptors; ALLERGIES; TRYPTASE
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 15, p3701
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20153701