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- Title
Time Is Running Out in Pulmonary Arterial Hypertension: The Epigenetic Clock Is Clicking.
- Authors
El Kabbout, Reem; Azhar, Nabil; Breuils-Bonnet, Sandra; Krishna, Vinod; Kalyana-Sundaram, Shanker; Boucherat, Olivier; Provencher, Steeve; Bonnet, Sébastien; Potus, François
- Abstract
The article focuses on pulmonary arterial hypertension (PAH), a condition characterized by increased pulmonary arterial pressure leading to right ventricular dysfunction and premature death. It explores the concept of biological aging acceleration in PAH, examining epigenetic age and age acceleration in various tissues/organs affected by the disease, suggesting a potential link between aging-related molecular dysfunctions and PAH progression.
- Subjects
PULMONARY arterial hypertension; ENDOTHELIN receptors; MOLECULAR biology; EPIGENETICS; PULMONARY circulation; CYTOLOGY; KILLER cells
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2024, Vol 70, Issue 2, p140
- ISSN
1044-1549
- Publication type
Article
- DOI
10.1165/rcmb.2023-0335le