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- Title
Possible association between TGF-β1 polymorphism and oral cancer.
- Authors
Carneiro, N. K.; Oda, J. M. M.; Losi Guembarovski, R.; Ramos, G.; Oliveira, B. V.; Cavalli, I. J.; S. F. Ribeiro, E. M.; Gonçalves, M. S. B.; Watanabe, M. A. E.
- Abstract
Oral squamous cell carcinoma ( OSCC) is a worldwide health problem because it is a great cause of cancer morbidity and mortality. The transforming growth factor-β1 ( TGF-β1) is involved in the regulation of numerous immunomodulatory processes. Thus, the aim of this case-control study was to investigate the possible association between the TGF-β1T869 C polymorphism and oral cancer. The genomic DNA extracted from peripheral blood of 62 male smoker patients diagnosed with OSCC and 62 smokers without cancer was analysed. The C allele was significantly more prevalent in the oral cancer group than in the controls, and individuals carrying this allele had an estimated 2.73-fold greater relative risk of developing cancer compared with C allele noncarriers ( OR = 2.73, 95% CI = 1.19-6.28). Although T allele was not statistically significant among the controls, considering the genotypic analysis, the TT homozygous genotype showed a protector effect in relation to oral cavity cancer ( OR = 0.37, 95% CI = 0.16-0.84). Some clinicopathological features were also analysed for genotype distribution, and no significant differences were observed: tumour size ( P > 0.70), nodal status ( P > 0.10) and tumour stage ( P > 0.70). This is the first report of a study assessing the importance of T869C TGF-β polymorphism in oral cancer. It is known that the TGF-β T869 C variation results in a Leu10 Pro substitution in the signal peptide sequence. Our results suggested that the C allele could increase TGF-β secretion which suppresses antitumour immune responses and may affect the OSCC risk.
- Subjects
TRANSFORMING growth factors; IMMUNOMODULATORS; GENETIC polymorphisms; ORAL cancer; ORAL diseases
- Publication
International Journal of Immunogenetics, 2013, Vol 40, Issue 4, p292
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/iji.12037