We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical features of gestational choriocarcinoma: A retrospective bicentric study.
- Authors
Yuksel, Dilek; Aytekın, Okan; Oktar, Okan; Ayhan, Sevgi; Ozkaya Ucar, Yesim; Cakır, Caner; Boran, Nurettin; Korkmaz, Vakkas; Koc, Sevgi; Türkmen, Osman; Kimyon Cömert, Günsu; Moraloğlu Tekin, Ozlem; Engin Ustün, Yaprak; Turan, Taner
- Abstract
Objective: To investigate the clinicopathological features, prognostic factors, treatment, clinical response, and outcome of gestational choriocarcinoma (GCC). Materials and methods: A retrospective review was made of the clinicopathological and survival data of 13 patients who were diagnosed and treated for GCC in two referral centers in Turkey between 1992 and 2020. Results: The median age of patients was 36 years (range, 27–54 years), and seven were ≤39 years. The antecedent pregnancy was a term in nine (69.2%) cases, and the risk score was ≥7 in 11 (84.6%). According to the International Federation of Gynecology and Obstetrics 2009 staging, eight cases were in stage I, two in stage III, and three in stage IV. With the exception of one patient, all the others received combination chemotherapy (CT), and two of those were also treated with radiotherapy. Chemoresistance developed in 50% (6/12), and second‐line CT was given to four of these. The overall complete response rate was 69.2%. Four patients died of chemoresistance and disease progression, all of them were with antecedent‐term pregnancy, had high scores ≥7, and had metastases. Conclusion: GCC is a unique subtype of gestational trophoblastic neoplasia, which differs from others in terms of poor prognosis, a frequent tendency to early metastasis, and resistance to treatment. To be able to achieve the most efficient therapy and prognosis, histopathology‐based risk models should be developed.
- Subjects
TURKEY; DISEASE risk factors; CHORIOCARCINOMA; GESTATIONAL trophoblastic disease; PROGNOSIS; DISEASE progression; TROPHOBLASTIC tumors; COMBINATION drug therapy
- Publication
Asia Pacific Journal of Clinical Oncology, 2024, Vol 20, Issue 2, p292
- ISSN
1743-7555
- Publication type
Article
- DOI
10.1111/ajco.13946