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- Title
Palladium-Catalyzed Divergent Arylation with Triazolopyridines: One-Pot Synthesis of 6-Aryl-2-α-styrylpyridines.
- Authors
Moon, Youngtaek; Kwon, Soonhyung; Kang, Dahye; Im, Honggu; Hong, Sungwoo
- Abstract
We have developed a new strategy for palladium-catalyzed arylation reactions with triazolopyridines, wherein two different chemical transformations (C-3 vs. C-7) are observed by differentiating the substrates using different bases. The reactive palladium carbenoids were directly generated from triazolopyridines and underwent denitrogenative arylations with aryl bromides. Intriguingly, when potassium carbonate was replaced with potassium tert-butoxide, direct CH arylation occurred at the most acidic position (C-7). Moreover, two different catalytic arylation events were successfully performed in a one-pot sequence, providing a convenient access to 6-aryl-2-α-styrylpyridines.
- Subjects
ARYLATION; PALLADIUM catalysts; PYRIDINE synthesis; CARBENE synthesis; CHEMICAL amplification; PALLADIUM compound synthesis
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 6, p958
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500967