We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical impact of admission urinary 8-hydroxydeoxyguanosine level for predicting cardiovascular mortality in patients with acute coronary syndrome.
- Authors
Gohbara, Masaomi; Iwahashi, Noriaki; Nakahashi, Hidefumi; Kataoka, Shunsuke; Takahashi, Hironori; Kirigaya, Jin; Minamimoto, Yugo; Akiyama, Eiichi; Okada, Kozo; Matsuzawa, Yasushi; Konishi, Masaaki; Maejima, Nobuhiko; Hibi, Kiyoshi; Kosuge, Masami; Ebina, Toshiaki; Sugano, Teruyasu; Ishikawa, Toshiyuki; Tamura, Kouichi; Kimura, Kazuo
- Abstract
The aim of the present study was to determine whether urinary 8-hydroxydeoxyguanosine (8-OHdG), which is a marker of oxidative stress, can predict future cardiovascular death in patients with acute coronary syndrome (ACS). A total of 551 consecutive patients with ACS who underwent admission urinary 8-OHdG measurements were enrolled in this study. The patients were divided into 2 groups according to the optimal cutoff value of admission urinary 8-OHdG determined by a receiver-operating characteristics curve for the prediction of cardiovascular death: a high admission urinary 8-OHdG group, 169 patients with admission urinary 8-OHdG ≥ 17.92 ng/mg creatinine; and a low admission urinary 8-OHdG group, 382 patients with admission urinary 8-OHdG < 17.92 ng/mg creatinine. The patients were followed up for a median period of 34 months. The primary and secondary end points were the incidence of cardiovascular death and major cardiovascular events (MACE) composed of cardiovascular death, non-fatal myocardial infarction, or urgent hospitalization for heart failure. Of the 551 patients, cardiovascular deaths and MACE occurred in 14 (2.5%) and 35 (6.4%), respectively. The Kaplan–Meier estimate of the event-free rate revealed cardiovascular deaths and MACE were more likely in the high admission 8-OHdG group than in the low admission 8-OHdG group (log rank, both P < 0.001). Multiple adjusted Cox proportional hazards analysis indicated that high admission urinary 8-OHdG was an independent predictor of cardiovascular death (hazard ratio [HR] 7.642, P = 0.011) and MACE (HR 2.153, P = 0.049). High admission urinary 8-OHdG levels predict cardiovascular mortality after adjustment in patients with ACS.
- Subjects
ACUTE coronary syndrome; CARDIOVASCULAR disease related mortality; HOSPITAL admission &; discharge; MYOCARDIAL infarction; MORTALITY
- Publication
Heart & Vessels, 2021, Vol 36, Issue 1, p38
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-020-01663-4