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- Title
A new approach to the chiral separation of novel diazenes.
- Authors
Vojtylová, Terézia; Niezgoda, Izabela; Galewski, Zbigniew; Hamplová, Věra; Sýkora, David
- Abstract
Two new types of potential liquid-crystalline azo compounds were synthesized in the form of racemic mixtures and as the individual S enantiomers. Both materials consisting of two substituted aromatic rings in the molecular core and one chiral center at the aliphatic moiety showed mesomorphic behavior. The separation of the R and S enantiomers by chiral highperformance liquid chromatography was unsuccessful when the azo compounds were in their natural E state. However, the irradiation of the compounds in the solution by UV light led to an almost quantitative transition to their Z forms. The chromatographic behavior of the compounds in their Z forms was significantly different, and partial separation of the individual enantiomers on chiral polysaccharide-based stationary phases was obtained. Thus, the proposed procedure represents a novel approach to the enantioseparation of chiral diazenes.
- Subjects
AZOBENZENE; SEPARATION technology equipment; DIAZENES; HIGH performance liquid chromatography; ISOMERIZATION
- Publication
Journal of Separation Science, 2015, Vol 38, Issue 24, p4211
- ISSN
1615-9306
- Publication type
Article
- DOI
10.1002/jssc.201500816