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- Title
Fat suppression for <sup>1</sup>H MRSI at 7T using spectrally selective adiabatic inversion recovery.
- Authors
Balchandani, Priti; Spielman, Daniel
- Abstract
Proton magnetic resonance spectroscopic imaging (1H MRSI) at 7T offers many advantages, including increased SNR and spectral resolution. However, technical difficulties associated with operating at high fields, such as increased B1 and B0 inhomogeneity, severe chemical shift localization error, and converging T1 values, make the suppression of the broad lipid peaks which can obscure targeted metabolite signals, particularly challenging. Conventional short tau inversion recovery can successfully suppress fat without restricting the selected volume, but only with significant metabolite signal loss. In this work, we have designed two new pulses for frequency-selective inversion recovery that achieve B1-insensitive fat suppression without degrading the signal from the major metabolites of interest. The first is a spectrally selective adiabatic pulse to be used in a volumetric 1H MRSI sequence and the second is a spatial-spectral adiabatic pulse geared toward multi-slice 1H MRSI. Partial interior volume selection may be used in addition to the pulses, to exclude areas with severe B0 inhomogeneity. Some differences in the spectral profile as well as degree of suppression make each pulse valuable for different applications. 7T phantom and in vivo data show that both pulses significantly suppress fat, while leaving most of the metabolite signal intact. Magn Reson Med 59:980-988, 2008. © 2008 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2008, Vol 59, Issue 5, p980
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.21537