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- Title
Quantitative determination of Gd-DTPA concentration in T<sub>1</sub>-weighted MR renography studies.
- Authors
Bokacheva, Louisa; Rusinek, Henry; Chen, Qun; Oesingmann, Niels; Prince, Chekema; Kaur, Manmeen; Kramer, Elissa; Lee, Vivian S.
- Abstract
A method for calculating contrast agent concentration from MR signal intensity (SI) was developed and validated for T1-weighted MR renography (MRR) studies. This method is based on reference measurements of SI and relaxation time T1 in a Gd-DTPA-doped water phantom. The same form of SI vs. T1 dependence was observed in human tissues. Contrast concentrations calculated by the proposed method showed no bias between 0 and 1 mM, and agreed better with the reference values derived from direct T1 measurements than the concentrations calculated using the relative signal method. Phantom-based conversion was used to determine the contrast concentrations in kidney tissues of nine patients who underwent dynamic Gd-DTPA-enhanced 3D MRR at 1.5T and 99mTc-DTPA radionuclide renography (RR). The concentrations of both contrast agents were found to be close in magnitude and showed similar uptake and washout behavior. As shown by Monte Carlo simulations, errors in concentration due to SI noise were below 10% for SNR = 20, while a 10% error in precontrast T1 values resulted in a 12-17% error for concentrations between 0.1 and 1 mM. The proposed method is expected to be particularly useful for assessing regions with highly concentrated contrast. Magn Reson Med 57:1012-1018, 2007. © 2007 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2007, Vol 57, Issue 6, p1012
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.21169