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- Title
Opsonophagocytosis versus Complement Bactericidal Killing as Effectors following Neisseria meningitidis Group C Vaccination.
- Authors
Gomez-Lus, M. L.; Giménez, M. J.; Vázquez, J. A.; Aguilar, L.; Anta, L.; Berrón, S.; Laguna, B.; Prieto, J.
- Abstract
Background: Opsonophagocytosis and complement-mediated Neisseria meningitidis killing after vaccination were investigated. Methods: Twelve seronegative healthy volunteers received one dose of polysaccharide A/C vaccine and were followed for 3 years. Ex vivo serum killing rates with polymorphonuclear cells (PMN) and/or complement were performed at 0, 1.5, 6, 12, 18, 24, 30 and 36 months. Results: High mean total and median bactericidal antibodies were detected over time in all subjects. Considerable reduction of the initial inoculum was obtained only in the presence of complement, with or without PMN (with significant differences compared to curves without complement) a long time after vaccination. Conclusion: PMN did not increase post-vaccination bacterial killing, suggesting that antibody complement-mediated killing, and not opsonophagocytosis, is the main immune effector of the vaccine protection against N. meningitidis.
- Subjects
PHAGOCYTOSIS; ANTIGEN-antibody reactions; IMMUNE response; NEISSERIA meningitidis; VACCINATION; NEUTROPHILS
- Publication
Infection, 2003, Vol 31, Issue 1, p51
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-002-3128-4