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- Title
Limbic-predominant age-related TDP-43 proteinopathy (LATE-NC) is associated with abundant TMEM106B pathology.
- Authors
Neumann, Manuela; Perneel, Jolien; Cheung, Simon; Van den Broeck, Marleen; Nygaard, Haakon; Hsiung, Ging-Yuek R.; Wynants, Sarah; Heeman, Bavo; Rademakers, Rosa; Mackenzie, Ian R. A.
- Abstract
We compared the presence and amount of TMEM106B pathology in cases with LATE-NC ( I N i = 19) to a control group of cases without any TDP-43 pathology ( I N i = 20) (Table 1, Table S1). Nonetheless, our findings (i) that LATE-NC is consistently associated with very high amounts of TMEM-ir pathology and (ii) that the amount of TDP-43 pathology and the presence of HS in the LATE-NC cases correlates with the amount of TMEM106B pathology, suggest that either significant TMEM106B pathology is a requirement for the formation of LATE-NC, or that the factors(s) responsible for the accumulation of TMEM106B CTFs also predispose to TDP-43 mis-metabolism. The results of these studies suggested that the accumulation of TMEM106B filaments is a common age-related process that is particularly pronounced and may contribute to disease in cases with a primary pathological diagnosis of FTLD with TDP-43 pathology (FTLD-TDP).
- Subjects
ENTORHINAL cortex; PATHOLOGY; FRONTOTEMPORAL lobar degeneration; IMMUNOGLOBULINS
- Publication
Acta Neuropathologica, 2023, Vol 146, Issue 1, p163
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-023-02580-2